山东省肾综合征出血热地鼠肾细胞灭活疫苗免疫效果及免疫策略研究

本文报告肾综合征出血热Ⅱ型地鼠肾细胞灭活疫苗在山东省高发人群接种后的免疫效果。疫苗初免３针后２周、１２个月血清中和抗体阳转率分别为６８．９６％（２０／２９）、１８．５％（５／２７），１２个月复种１针后血清中和抗体阳转率达１００％（２７／２７）（ＭＣＰＥＮＴ法）；几何平均滴度（ＧＭＴ）为８．４、３．２、１７．０５。通过１９９５年春峰及秋冬峰本病高峰期观察，接种人群未发生病人，对照人群发病２５例，发病率２１０．９／１０万，疫苗保护率１００％，疫苗接种无明显不良反应，安全性较好，近期免疫、防病效果较理想。

Immune Effect and Tactics of Inactivated Vaccine against HFRS

The study reported the immune effect of inactivated vaccine prepared from golden hamster cells on the population with high morbidity in the area, and with high incidence rate. The neutralizing antibodies were measured by the MCPENT assay. In 2weeks, 12 months after three injections, the seroconversion rates of neutralizing antibodies were 68. 96 % (20/29) , 18. 5 % (5/27) respectively. After four injections in 12 months, the seroconversion rate of neutralizing antibody was 100 % (27/27). Geometric mean titers were 8.4, 3.2, 17. 05, respectively. Through the spring and autumn peaks of HFRS in 1995, there were no patients in the immunized group and 25 patients in the control group. The morbidity rate was 210.9/100 000, protective rate was 100 %. There were no adverse effect after immunization.These data demonstrated that the vaccine was safe and had a satisfied effect against HFRS in short period.