| 培多普利及洛沙坦对心肌成纤维细胞生长的影响 |
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| 引用本文： | 何兰杰,常文静,张福建,陈曦. 培多普利及洛沙坦对心肌成纤维细胞生长的影响[J]. 宁夏医学杂志, 2002, 24(5): 265-266 |
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| 作者姓名： | 何兰杰 常文静 张福建 陈曦 |
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| 作者单位： | 1. 宁夏医学院附属医院,宁夏,银川,750004
2. 北京阜外医院生化研究所,北京,100730 |
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| 基金项目： | 1998年度卫生部项目基金，1 998年北京市自然科学基金资助 (编号 :7982 0 31 ) |
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| 摘 要： | 目的 观察培多普利及洛沙坦对体外培养的乳鼠心肌成纤维细胞生长的影响。方法 体外培养心肌成纤维细胞及3 H -TdR参入。结果 两种药物对不同细胞周期的心肌成纤维细胞有生长抑制作用。结论 培多普利及洛沙坦对心肌肥厚可能有抑制作用。
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| 关 键 词： | 培多普利 洛沙坦 心肌重塑 |
| 文章编号： | 1001-5949(2002)05-0265-02 |
| 修稿时间： | 2001-05-08 |
Effect of perindopril and losartan on proliferation of myocardial fibroblasts |
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| HE Lan-jie,et al.. Effect of perindopril and losartan on proliferation of myocardial fibroblasts[J]. Ningxia Medical Journal, 2002, 24(5): 265-266 |
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| Authors: | HE Lan-jie et al. |
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| Abstract: | Objectives To observe the effect of perindopril and losartan on myocardial fibroblasts.Methods Cultured myocardial fibroblasts were inhibited at G 0/G 1 or G 2-phase then incubated with different concentrations of perindopril or loartan , their effects on the growth of cultured myocardial fibroblasts were studied by 3H-TdR incorporation.Results Perindopril and losartan inhibited DNA synthesis of myocardial fibroblasts in both G 0/G 1- and G 2-phase.Conclusions There may be inhibited proliferation of myocardial fibroblasts. |
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| Keywords: | Perindopril Losartan Heart remodeling |
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