Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol

Authors:	Matthew J. Pava Emily M. Blake Stephen T. Green Brandon J. Mizroch Patrick J. Mulholland John J. Woodward

Affiliation:	(1) Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA;(2) Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, SC, USA;(3) Program in Neuroscience, College of Charleston, Charleston, SC, USA;(4) MUSC IOP 4 North, MSC 861, Charleston, SC 29425, USA;

Abstract:	Rationale Chronic ethanol (EtOH) treatment decreases the motor-impairing effects of cannabinoids and downregulates the cannabinoid type 1 (CB1) receptor. However, these studies have been limited to measures of ataxia and analysis of CB1 expression from whole-brain or hippocampal preparations.

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