356例产前诊断结果评价、安全性分析

目的]评价产前诊断指证在胎儿染色体病诊断中的意义,探讨产前诊断技术成功率和安全性。方法]对356例有产前诊断指征的孕妇,进行羊膜腔穿刺术或脐血穿刺术,取羊水细胞或脐血细胞培养,做胎儿染色体核型分析。结果]349例孕妇共检出胎儿染色体异常7例,染色体异常率为2.01%,产前胎儿异常标记组、孕母血清唐氏筛查阳性组和高龄孕妇组的异常率分别为27.27%、1.14%和2.08%,显著高于一般人群的异常率。脐血穿刺流产率为1%,羊水穿刺为0。结论合理应用产前诊断指证可以明显提高染色体病的产前诊断效力,选择适宜的产前诊断技术降低并发症的产生。

SAFETY ANALYSIS OF PRENATAL DIAGNOSES OF 356 CASES AND RESULTS EVALUATION

Objective]To evaluate the significance of the prenatal diagnosis indications for diagnosis of chromosome disease.To investigate the success rate and safety of prenatal diagnosis.Methods]A total of 356 cases with prenatal diagnosis were enrolled into this study.Amniotic fluid and fetal blood from them were obtained.And chromosomal karyotypes were determined.Results]Among 349 cases,7 cases of fetus’ chromosomal abnormalities were detected,and the abnormal incidence was 2.01%.In groups of abnormal ultrasonography markers,positive screening of Down’s syndrome and advanced maternal age,the abnormal incidences were 27.27%,1.14% and 2.08% respectively,which were higher markedly than in common population.The rate of abortions and premature delivery was 1% by cordocentesis,which was 0 by amniocentesis.Conclusion]The effectiveness of prenatal diagnosis for diagnosis of chromosome disease can be increased with proper application of prenatal diagnosis indications.And it choose the rational way of the prenatal diagnosis for reducing the complication.