| 选择性血管扩张剂对急性脑梗死患者血清IL-6、S100B影响 |
| |
| 引用本文： | 邓丹,李雪松,王铁燕,钟志强,王立峻,张继红,宫旭海.选择性血管扩张剂对急性脑梗死患者血清IL-6、S100B影响[J].中国伤残医学,2012,20(4):36-38. |
| |
| 作者姓名： | 邓丹 李雪松 王铁燕 钟志强 王立峻 张继红 宫旭海 |
| |
| 作者单位： | 大庆油田总医院神经内科,黑龙江,大庆,163001 |
| |
| 摘 要： | 目的:探讨应用前列地尔在治疗脑干梗死急性期对于白细胞介素-6(IL-6)、S100B蛋白表达的影响。方法:用双抗体夹心酶联免疫法测定60例急性脑干梗死患者血清IL-6、S100B蛋白水平变化,并根据神经功能缺损(NIHSS)评分、Barthel指数评分(BI)判断前列地尔治疗对于急性期脑干梗死疗效。结果:前列地尔组在治疗急性期脑干梗死第3天可以显著降低IL-6、S100B的表达,第14天时下降更为显著,同时可以显著降低(NIHSS)评分、提高BI评分,提高疗效。2组比较具有统计学差异(P<0.05)。结论:应用前列地尔可以显著降低IL-6、S100B的表达,改善脑干梗死的预后。
|
| 关 键 词： | 急性脑干梗死 选择性血管扩张剂 IL-6 S100B |
Selective Vasodilator Therapy Evaluation of Acute Brainstem Infarction on Serum IL-6,S100B Effects |
| |
| Institution: | DENG Dan,LI Xue-song,WANG Tie-yan,et al.(Department ofNeurology,The Daqing General Oil Field Hospital of Heilongjiang 163001) |
| |
| Abstract: | Objective:To investigate Lipo-PGE1 in the treatment of acute brainstem infarction for interleukin-6(IL-6),S100B protein expression.Methods:Double antibody sandwich ELISA method in 60 patients with acute brainstem infarction patients IL-6,S100B protein levels and,based on neurological deficit(NIHSS) score,Barthel Index score(BI) to judge Lipo-PGE1 treatment for acute brainstem infarction.Results:Lipo-PGE1 group in the treatment of acute brainstem infarction on the third day could significantly reduce the IL-6,S100B expression on day 14 decreased more significantly at the same time could significantly reduce(NIHSS) score,BI score increased,increase efficacy.Two groups had significant difference(P<0.05).Conclusions:Application of Lipo-PGE1 caould significantly reduce the IL-6,S100B expression,to improve the prognosis of brainstem infarction. |
| |
| Keywords: | Acute cerebral stem infarction Selected VA IL-6 S100B |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
