| 17种生物碱类药物体外经皮渗透行为的实验研究 |
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| 引用本文： | 许景峰.17种生物碱类药物体外经皮渗透行为的实验研究[J].解放军药学学报,2001,17(2):66-68. |
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| 作者姓名： | 许景峰 |
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| 作者单位： | 中国人民解放军北京军区总医院,药理科 |
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| 摘 要： | 目的 研究生物碱类药物经皮吸收系数与药物油 /水分配系数的关系。方法 采用Ficks扩散装置测定 17种生物碱类药物在小鼠皮的透皮速率 ,并与含 2 %促渗剂氮酮比较。结果 生物碱类药物的经皮渗透系数 (kp )与药物油 /水分配系数(logk )的关系式为 :logkp =7.35× 10 -2 - 3.0 79× 10 -2 logk - 8.11(logk) 2 ;logkp( 2 %Azo) =8.32× 10 -2 - 2 .6 8× 10 -2 logk - 5 .2 7(logk ) 2 ;结论 17种药物的油 /水分配系数平均最佳值为 2 .83,含 2 %氮酮后的其平均最佳值为 3.17。
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| 关 键 词： | 药物透皮吸收 药物油 水分配系数 氮酮 |
| 文章编号： | 1008-9926(2001)02-0066-03 |
| 修稿时间： | 2000年7月17日 |
To Study in Vitro Percutaneous Absorption of 17 Alkaloidal Drugs with Mouse Skin |
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| XU Jing-feng.To Study in Vitro Percutaneous Absorption of 17 Alkaloidal Drugs with Mouse Skin[J].Pharmaceutical Journal of Chinese People's Liberation Army,2001,17(2):66-68. |
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| Authors: | XU Jing-feng |
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| Abstract: | Aim To study the relationship between permeability coefficient and oil/water partition coefficient of 17 alkaloidal drugs.Methods The percutaneous absorption speed of 17 alkaloidal drugs were studied in mouse with improved Fick's diffusing device.Results The relationship between permeability coefficient (kp) and oil/water partition coefficient (logk) of 17 alkaloidal drugs or drugs containing 2% Azone can be described as following equations.logkp=7.35×10-2-3.079×10-2logk-8.11(logk)2;logkp(2%Azo)=8.32×10-2-2.68×10-2logk-5.27(logk)2,respectively.Conclusion ko/w and ko/w(2%Azo) was 2.83 and 3.17 respectively. |
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| Keywords: | The percutaneous absorption Oil/water partition coefficient Azone |
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