| 泛素-蛋白酶体系统影响认知功能的分子机制 |
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| 引用本文： | 张豪,海舰. 泛素-蛋白酶体系统影响认知功能的分子机制[J]. 国际脑血管病杂志, 2008, 16(11): 862-865 |
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| 作者姓名： | 张豪 海舰 |
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| 作者单位： | 同济大学附属同济医院神经外科,上海,200065 |
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| 摘 要： | 作为一种高效蛋白质降解途径,泛素-蛋白酶体系统(ubiquitin-proteasomc system,UPS)在维持细胞功能方面具有重要作用.在认知功能的分子机制方面,UPS的作用正成为新的研究热点.UPS主要作用于神经递质及其受体、突触调节、突触后电位长时程增强以及神经细胞内信号转导等,有可能成为对认知功能障碍进行干预的新靶点.
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| 关 键 词： | 泛素蛋白酶体系统 认知功能 分子机制 |
The Molecular Mechanisms of Ubiquitin-Proteasome System Effecting on Cognition |
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| Hao Zhang,Jian Hai. The Molecular Mechanisms of Ubiquitin-Proteasome System Effecting on Cognition[J]. International Journal of Cerebrovascular Diseases, 2008, 16(11): 862-865 |
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| Authors: | Hao Zhang Jian Hai |
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| Abstract: | As a highly efficient protein degradation pathway,ubiquitin-proteasome system(UPS) plays an important role in maintaining cell function.The role of UPS is becoming a new research focus in molecular mechanism of cognitive function.UPS mainly acts on neurotrans mitter and its receptor,synaptic reguIation,long-term potentiation of postsynaptic poteraiais and neuronal signal transduction,and it may become a new target for the intervention of cognitive dysfunction. |
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| Keywords: | ubiquitin-proteasome system cognitive fumtion molecular mechanism |
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