Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats |
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Authors: | Cos Samuel Mediavilla Dolores Martínez-Campa Carlos González Alicia Alonso-González Carolina Sánchez-Barceló Emilio J |
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Affiliation: | Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, 39011 Santander, Spain. |
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Abstract: | In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments. Animals exposed to light-at-night, especially those under a constant dim light during the darkness phase, showed: (a) significantly higher rates of tumor growth as well as lower survival than controls, (b) higher concentration of serum estradiol, and (c) lower nocturnal excretion of 6-sulfatoxymelatonin, without there being differences between nocturnal and diurnal levels. These results suggest that circadian and endocrine disruption induced by light pollution, could induce the growth of mammary tumors. |
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Keywords: | Mammary cancer Light 6-Sulfatoxymelatonin DMBA Melatonin Estradiol |
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