Dissecting the complexity of the memory T cell response |
| |
Authors: | Farber Donna L Ahmadzadeh Mojgan |
| |
Institution: | (1) Present address: Department of Surgery, Division of Transplantation, University of Maryland Medical School, Room 400 685 W, Baltimore St, 21201 Baltimore, MD |
| |
Abstract: | Memory immune responses are classically attributed to the reactivation of long-lived, antigen-specific T lymphocytes that
persist in a quiescent state. Determining mechanisms for the generation of memory T cells and dissecting the functional nature
of the memory T cell pool has been encumbered by an inability to distinguish recently activated effector T cells from memory
T cells. We have established new activation and biochemical criteria that distinguish effector and memory T cells and have
applied these criteria to follow memory generation from activated cells in vivo. We found that the resultant memory T cell
pool is heterogeneous and consists of effector-like and resting memory-like subsets that differ in expression of the homing
receptor, CD62L. We discuss these findings in the context of memory T cell heterogeneity identified in human and mouse systems.
These results suggest that more than one type of previously activated T cell can mediate recall or memory immune responses
and that elucidating the fundamental phenotypic and functional features of memory T cell subsets is therefore critical to
deciphering the complex nature of the memory immune response. |
| |
Keywords: | T lymphocytes Immune memory Effector cells CD62L Signal transduction |
本文献已被 PubMed SpringerLink 等数据库收录! |