| Galectin-3和血管内皮生长因子在喉鳞状细胞癌组织中的表达 |
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| 引用本文： | 孔红,崔俊生,王连友,董震.Galectin-3和血管内皮生长因子在喉鳞状细胞癌组织中的表达[J].临床耳鼻咽喉头颈外科杂志,2009,23(3). |
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| 作者姓名： | 孔红 崔俊生 王连友 董震 |
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| 作者单位： | 1. 吉林大学中日联谊医院耳鼻咽喉-头颈外科,长春,130033
2. 吉林大学中日联谊医院病理科 |
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| 基金项目： | 吉林省发改委资助项目，国家自然科学基金 |
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| 摘 要： | 目的:探讨喉鳞状细胞癌组织中Galectin-3和血管内皮生长因子(VEGF)蛋白表达及其在肿瘤分化,生长及转移中的相关意义.方法:应用免疫组织化学SP法和免疫印记法分别对29例喉鳞状细胞癌、18例喉良性病变组织中Galectin-3和VEGF蛋白表达水平进行了检测.结果:Galectin-3(89.7%)和VEGF(86.2%)在喉鳞状细胞癌组的阳性表达率与正常对照组比较均差异有统计学意义(均P＜0.05).喉高分化鳞状细胞癌组织中Galectin-3的表达与低分化鳞状细胞癌相比差异有统计学意义(P＜0.05);并凡,Galectin-3与VEGF在喉鳞状细胞癌组织中的表达呈正相关关系(r=0.423,P＜0.05).结论:喉鳞状细胞癌组织中Galectin-3和VEGF的高表达可能对肿瘤的组织分化和转移起重要作用.
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| 关 键 词： | 喉肿瘤 半乳糖凝集素-3 血管内皮生长因子 |
The expression of Galectin-3 and VEGF in laryngeal squamous cell carcinoma |
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| KONG Hong,CUI Junsheng,WANG Lianyou,DONG Zhen.The expression of Galectin-3 and VEGF in laryngeal squamous cell carcinoma[J].Journal of Clinical Otorhinolaryngology,2009,23(3). |
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| Authors: | KONG Hong CUI Junsheng WANG Lianyou DONG Zhen |
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| Institution: | 1Department of Otorhinolaryngology Head and Neck Surgery;China-Japan Union Hospital of Jilin University;Changchun;130033;China;2Department of Pathology;China-Japan Union Hospital of Jilin University |
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| Abstract: | Objective:To investigate the expression of galectin-3 and VEGF in laryngeal squamous cell carcinoma (LSCC) tissue and to analyze its role in differentiation,growth and metastasis of the tumor.Method:The expression of galectin-3 and VEGF were detected with SP immunohistochemistry staining and western blot in twenty-nine specimens of LSCC and eighteen specimens of laryngeal benign lesion.Result:The expression of galectin-3 (89.7%) and VEGF (86.2%) in LSCC were remarkably higher than that in normal control tis... |
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| Keywords: | laryngeal neoplasms Galectin-3 vascular endothelial growth factor |
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