Efficacy of skin barrier creams |
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Authors: | Peter J. Frosch Astried Schulze-Dirks Monika Hoffmann Inge Axthelm |
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Affiliation: | Hautklinik der Städtischen Kliniken, Dortmund. Germany;Department of Dermatology, University of Heidelberg, Germany |
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Abstract: | An animal model for the evaluation of skin protective creams against chemical irritants is described. The irritants were applied daily for 2 weeks to shaved back skin of young guinea pigs: sodium tauryl sulphate (5% aq.: 30 min), sodium hydroxide (0,5% aq.; 2 min). and toluene (20'i. eth.; 2 mint. "The harrier cream was applied 2 h prior to and immediately after exposure to the irritant. Control animals were treated with the irritant only. The irritant reaction was scored on a 4–point scale for erythema and quantified with regard to transepidennal water loss (TEWL) by evaporime-try and skin blood flow volume (BFV) by laser Doppler velocimetry. A total of 90 guinea pigs, consisting of" individual panels of 5 to 10 animals, was tested. While one barrier cream (Slokoderm) significantly suppressed the irritation due 10 sodium lauryl sulphate and toluene, the other (Contra-Alkalh failed to do so and even aggravated the response, which was particularly evident with sodium hydroxide. This model may be useful in developing more effective barrier creams. |
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Keywords: | prevention: barrier creams: irritation sodium lauryl sulphate sodium hydroxide toluene guinea pigs transepidermal water loss blood How |
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