| 双氯灭痛结肠靶向脉冲控释片的研究 |
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| 引用本文： | 严轶东,崔京浩,全姬善,朴美香.双氯灭痛结肠靶向脉冲控释片的研究[J].延边医学院学报,2003,26(4):269-272. |
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| 作者姓名： | 严轶东 崔京浩 全姬善 朴美香 |
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| 作者单位： | [1]延边大学药学院药荆学教研室，吉林延吉133000 [2]延边社会精神病防治院药局，吉林延吉133000 |
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| 摘 要： | 目的 ]以双氯灭痛为模型药物 ,研制脉冲控释片并考察其体外释放的影响因素 .方法 ]以乙基纤维素和丙烯酸树脂为包衣材料制备包衣片 ,通过体外释放度的测定来考察片芯及包衣材料等因素对脉冲控释片体外释放的影响 .结果 ]崩解剂的用量、包衣液中致孔剂的用量及包衣膜的厚度为影响药物体外释放的主要因素 ,可以根据需要调节药物的释放时滞 .结论 ]双氯灭痛脉冲控释片在体外具有脉冲释放特性
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| 关 键 词： | 药物设计 剂型 给药系统 双氯酚酸 |
| 文章编号： | 1000-1824(2003)04-0269-04 |
| 修稿时间： | 2003年10月11 |
Studies on pulsatile controlled release tablets of diclofenac sodium |
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| YAN Yi-dong ,CUI Jing-hao ,QUAN Ji-shan ,PIAO Mei-xiang.Studies on pulsatile controlled release tablets of diclofenac sodium[J].Journal of Medical Science Yanbian University,2003,26(4):269-272. |
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| Authors: | YAN Yi-dong CUI Jing-hao QUAN Ji-shan PIAO Mei-xiang |
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| Institution: | YAN Yi-dong 1,CUI Jing-hao 1,QUAN Ji-shan 1,PIAO Mei-xiang 2 |
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| Abstract: | OBJECTIVETo prepare the pulsatile contro ll ed release tablets (PCRT) of diclofenac sodium (DS) as a drug model and investig ate the influence factors in vitro release.METHODSThe PCRT o f DC with ethycellulose (EC) and acrylic resin as coating materials were prepar ed by using coating technique. The influence factors on the lag time were invest igated by dissolution test.RESULTSThe amount of disintegrant s, the coating weight and the concentration of the pore former had significa nt e ffects on the lag time of DS from PCRT. The lag time could be controlled by adju stment if needed.CONCLUSIONThe PCRT had the pulsatiling property in vitro release test. |
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| Keywords: | drug design dosage forms medication systems diclofena c |
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