DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT |
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| Authors: | Klaus Rother, Ursula Rother, Hans J. Mü ller-Eberhard, Ulf R. Nilsson |
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| Affiliation: | From the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California |
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| Abstract: | A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form. |
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