血清肿瘤标志物CEA、CYFRA21-1、CA50、CA19-9、CA125联合检测对肺癌的诊断价值探讨

目的　探讨肿瘤标志物 CEA、CYFRA2 1- 1、CA5 0、CA19- 9、CA12 5辅助诊断肺癌的临床应用价值。方法　采集 16 0例住院患者的血清 ,其中肺癌 131例 ,肺部良性病变 (BL D) 2 9例 ,用化学发光法检测其血清癌胚抗原 (CEA)、糖链抗原 (CA19- 9)、糖链抗原 (CA12 5 ) ,用免疫放射法检测血清糖链抗原 (CA5 0 )、细胞角质蛋白19(CYFRA2 1- 1)的含量。结果　肺癌组患者血清 CEA、CYFRA2 1- 1、CA5 0、CA19- 9、CA12 5含量明显高于 BL D(P<0 .0 0 1) ;CEA+CYFRA2 1- 1+CA19- 9、 CEA+CYFRA2 1- 1+CA5 0和 CEA+CYFRA2 1- 1+CA12 5联合检测肺癌敏感性较单项检测提高 ,分别为 71.6 %、 79.1%、 83.7% ;CEA、 CA5 0、 CA12 5、 CA19- 9、 CYFRA2 1- 1的含量随肺癌病情进展和分期而升高。结论　肺癌患者血清 CEA、CYFRA2 1- 1、CA5 0、CA19- 9、CA12 5含量明显高于 BL D。血清肿瘤标志物联合检测可提高诊断肺癌敏感性。

Combined assay with serum tumor markers of CEA,CYFRA21-1,CA50,CA19-9,CA125 for lung cancer diagnosis

Objective To study the clinic significance of tumor markers CEA,CYFRA21-1,CA50,CA19-9,CA125 in assistant diagnosis of lung cancer.Methods One hundred and sixty serum samples were collected in-patients,131 from lung cancer and 29 from benign lung diseases(BLD),the concentration of serum CEA,CYFRA21-1,CA50,CA19-9,CA125 were detected by immunoradiometric assay or automated chemiluminescence assay.Results The CEA,CYFRA21-1,CA50,CA19-9,CA125 were higher in lung cancer group than BLD group (P<0.01),the sensitivity of tumor markers combined assay(CEA+CYFRA21-1+CA19-9,CEA+CYFRA21-1+CA50,CEA+CYFRA21-1+CA125)was raised respect to 71.6%,79.1%,and 83.7%.In advanced lung cancer group,the concentrations of serum CEA,CYFRA21-1,CA50,CA19-9,CA50 were higher.Conclusion In lung cancer patient,the concentration of serum CEA,CYFRA21-1,CA50,CA19-9,CA50 is significantly higher than BLD.The sensitivity of lung cancer diagnosis is raised by combined assay with serum tumor marker.