| 维胺酸对实验性口腔癌阻断作用的研究 |
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| 引用本文： | 孙正 李宁. 维胺酸对实验性口腔癌阻断作用的研究[J]. 口腔医学, 1999, 19(4): 182-183 |
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| 作者姓名： | 孙正 李宁 |
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| 作者单位： | 首都医科大学附属北京口腔医院!100050(孙正，刘萍)，中国预防医学科学院营养与食品卫生研究所!100050(李宁) |
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| 摘 要： | 目的观察维胺酸对实验性口腔癌的阻断作用方法以DMBA诱导的金黄地鼠口腔癌为模型用维胺酸进行治疗结果维胺酸对癌前病变有明显的阻断作用各治疗组与对照组相比均有显著性差异同时发现维胺酸可降低口腔粘膜细胞微核细胞率结论维胺酸对DMBA引起的粘膜组织DNA损伤有保护作用对实验性口腔有阻断作用
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| 关 键 词： | 维胺酸 口腔癌 微核 |
Study of the Effects of Retinamide on DMBA-Induced Oral Carcinogenesis in Hamsters |
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| Sun Zheng,Liu Ping. Study of the Effects of Retinamide on DMBA-Induced Oral Carcinogenesis in Hamsters[J]. Stomatology, 1999, 19(4): 182-183 |
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| Authors: | Sun Zheng Liu Ping |
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| Affiliation: | Sun Zheng,Liu Ping.Beijing Hospital for Stomatology Capital University of Medical Sciences Beijing |
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| Abstract: | Objective:Studies of the effects of retinamide on DMBA-induced Oral carcinogenesis in hamsters.Methods:Inhibition of buccal pouch carcinogenesis induced by dimethyl-benzanthracene in hamsters with retinamide.Results:Experiments exhibited that under the action of retinamide the incidence of tumor was lowered.All the goup with retinamide had a good response.Conclutions:The results showed that retinamide could reduce micronuclei formation.Protecting DNA damage and suppression of cell proliferation were considered as important mechanisms of the anticarcinogenic effects of the retinamide. |
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| Keywords: | Retinamide Oral cancer Micronuclei |
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