P-ERG在糖尿病性视网膜病变诊断和治疗中的应用研究

本实验对正常人20例(40眼)和64例糖尿病患者(128眼,其中无视网膜病者62眼,单纯型视网膜病变者58眼,增殖型视网膜病变者8眼),进行了图形视网膜电图(P-ERG)检测.并对进行光凝治疗的31眼在治疗前当日,治疗后7天、14天、30天、60天时分别测定P-ERG.结果显示,在糖尿病组中,当眼底尚未出现改变时,P-ERG各参数值已有变化,b波波幅降低,潜伏期延长(P＜0.01).随着糖尿病性视网膜病变(DR)的发展,变化更加显著,组间差异逐渐加大.P-ERG的b波波幅和潜伏期分别与糖尿病病程显著相关.光凝治疗后7天,P-ERG的b波波幅出现明显但暂时的降低,随后逐渐恢复到治疗前水平.b波潜伏期在治疗前后无明显变化.结果揭示P-ERG在DR的早期诊断方面具有高度敏感性,通过检测糖尿病者的P-ERG可以预测DR的发生、发展,估计DR的严重程度.同时P-ERG还可以做为对接受光凝治疗的DR者的视网膜功能的监测手段.

P-ERG in diabetic retinopathy

The pattern electroretinogram (P-ERG) were examined in 20 normal individuals (40 eyes) and 64 patients (128 eyes) with diabetes mellious (DM). We also recorded the P-ERG at 5 different time points in 31 eyes of patients who had argon laser photocoagulation, i.e.: before treatment, and 7, 14, 30, and 80 days after laser treatment. The results showed that P-ERG had already changed in the DM patients whose ocular fungus had no changes. With the development of diabetic retinopathy (DR), the P-ERG showed further impairments, and the differences between groups increased gradually. The changes in P-ERG were related to the diabetic courses. There was an obvious but temporary depression of P-ERG amplitude at 1 week post-photocoagulation, then the value returned to baseline gradually. The b-wave latency remained constant after the treatment. 'The results suggested that P-ERG has high sensitivity in the early diagnosis of DR and it also can be used to predict the progress and extent of the retinopathy.