Apolipoprotein E genotypes and longevity across dementia disorders |
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| Authors: | Tobias Skillbäck Ronald Lautner Niklas Mattsson Jonathan M. Schott Ingmar Skoog Katarina Nägga Lena Kilander Anders Wimo Bengt Winblad Maria Eriksdotter Kaj Blennow Henrik Zetterberg |
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| Affiliation: | 1. Department of Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden;2. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden;3. Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden;4. Department of Neurology, Skåne University Hospital, Lund, Sweden;5. Dementia Research Centre, UCL Institute of Neurology, London, UK;6. Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden;g. Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden;h. Department of Neurobiology, Care Sciences, and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden;i. Centre for Research & Development Uppsala University/County Council of Gävleborg, Gävle, Sweden;j. Department Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden;k. Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK |
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| Abstract: | IntroductionThe ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied.MethodsWe used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity.ResultsThe ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders.DiscussionThe APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common. |
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| Keywords: | Apolipoprotein E Alzheimer's disease Dementia with Lewy bodies Vascular dementia Frontotemporal dementia Parkinson's disease dementia Creutzfeldt-Jakob disease |
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