| 刮筋板乙酸乙酯部位化学成分 |
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| 引用本文： | 李云志,马超,黄静. 刮筋板乙酸乙酯部位化学成分[J]. 中国中药杂志, 2010, 35(9): 1145-1147 |
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| 作者姓名： | 李云志 马超 黄静 |
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| 作者单位： | 1. 安徽农业大学,茶叶生物化学与生物技术教育部重点实验室,安徽,合肥,230036;四川大学,华西药学院,四川,成都,610041
2. 四川大学,华西药学院,四川,成都,610041 |
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| 摘 要： | 目的:研究刮筋板Excoecaria acerifclia的化学成分和生物活性.方法:采用色谱技术分离纯化,根据化学成分理化性质和波谱数据确定化学结构;MTT法测定化合物对人肝癌细胞系(human hepatocarcinoma cell line)HepG2的体外抑制作用,用半数抑制浓度(IC50)评价其抗肿瘤活性.结果:分离鉴定了8个化合物,分别为6-甲氧基-7-羟基香豆素(1),6,7-二甲氧基-8-羟基香豆素(2),山柰酚(3),山柰酚3-O-吡喃葡萄糖苷(4),槲皮素-3-O-β-D-葡萄糖糖苷(5),山奈酚-3-O-β-D-葡萄糖糖苷-2"-没食子酸酯(6),β-谷甾醇(7),胡萝卜苷(8).生物活性研究显示化合物5和6对人肝癌细胞系HepG 2的IC50分别为7.13,65.42μmol·L-1.结论:所有化合物均为首次从该植物中分得.化合物5具有较好的体外抑制HepG2作用.
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| 关 键 词： | 刮金板 化学成分 生物活性 |
| 收稿时间： | 2009-09-10 |
Chemical constituents from Excoecaria acerifclia and their bioactivites |
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| LI Yunzhi,MA Chao and HUANG Jing. Chemical constituents from Excoecaria acerifclia and their bioactivites[J]. China Journal of Chinese Materia Medica, 2010, 35(9): 1145-1147 |
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| Authors: | LI Yunzhi MA Chao HUANG Jing |
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| Affiliation: | Key Laboratory of Tea Biochemistry and Biotechnology, Ministry of Education, Anhui Agricultural University, Hefei 230036, China;West China School of Pharmacy , Sichuan University, Chengdu 610041, China;West China School of Pharmacy , Sichuan University, Chengdu 610041, China;West China School of Pharmacy , Sichuan University, Chengdu 610041, China |
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| Abstract: | Objective:To investigate the chemical constituents of Excoecaria acerifclia and their antitumor activities.Method: The constituents were isolated and purified by column chromatography.Their structures were identified by their physicochemical properties and spectral features.Cytotoxicities of the purified compounds were evaluated by MTT method against human cancer cell lines HepG2.Result: Eight compounds were isolated and identified as: 7-hydroxy-6-methoxy-coumarin (1), 8-hydroxy-6,7-methoxy-coumarin (2), ka... |
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| Keywords: | Excoecaria acerifclia chemical constituents bioactivity |
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