妊娠期肝内胆汁淤积症患者血清及新生儿脐血中可溶性细胞间粘附分子-1的检测及临床意义

目的 :检测妊娠期肝内胆汁淤积症 (ICP)患者血清及新生儿脐血中可溶性细胞间粘附分子 - 1(SICAM - 1)及其临床意义。方法 :采用酶联免疫吸附法 (ELISA)检测各项指标。结果 :(1)ICP患者血清、新生儿脐血中SICAM - 1的浓度明显高于正常孕妇组 (P<0 .0 1) ,随着ICP程度的增加 ,SICAM - 1的浓度逐渐增高 (P <0 .0 5 ) ;两组孕妇产后 1周母血中SICAM - 1逐渐降至正常 (P >0 .0 5 ) ;(2 )ICP患者血清中SICAM - 1的升高与胆汁酸 (BA)、ALT、AST呈正相关 (P <0 .0 0 1,P <0 .0 0 5 )。结论 :ICP患者血清、新生儿脐血中SICAM - 1含量的升高在ICP的发病中可能有一定的作用

Detection of soluble intercellular adhesion molecule-1 in the serum of patients with intrahepatic cholestasis of pregnancy and neonate's cord blood and their clinical significance

Objective:To detect the serum of soluble intercellular adhesion molecule-1 (SICAM-1) in patients with intrahepatic cholestasis of pregnancy (ICP) and neonate's cord blood and their clinical significance.Methods:Each index was detected by ELISA.Results:(1)The concentration of SICAM in the serum of patients with ICP and neonate's cord blood was higher than that in normal pregnancy group significantly (P<0.01).The concentration of SICAM-1 became higher with the severity of ICP(P<0.05).The level of SICAM-1 in pregnancies of two groups decreased gradully one week after delivery.(2) The level of SICAM-1 from women with ICP had a significant positive correlation with bile acid (BA),ALT and AST (P<0.001,P<0.01,P<0.05,respectively). Conclusions:There is an important role of elevated maternal serum and neonate's cord blood levels of SICAM-1 in genesis of patients with ICP.