Abstract: | The circadian variation of different fractions of serum acid phosphatase was determined in two men with a normal prostate, two men with benign prostatic hyperplasia, and four men with prostatic cancer. Serum samples were obtained every 2 hours from 8:00 a.m. until 6:00 a.m. the following day. An overall sample standard deviation of 1.98 U/liter was calculated for total acid phosphatase, 0.4 U/liter for tartrate-labile acid phosphatase, and 0.13 micrograms/liter for prostatic acid phosphatase as determined by immunoenzyme assay. |