Initial detection of [H]clonidine binding to solubilized rat brainα<sub>2</sub>-adrenergic receptors: regulation by guanine nucleotides期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Initial detection of [H]clonidine binding to solubilized rat brainα₂-adrenergic receptors: regulation by guanine nucleotides

Authors:	Hiroaki Matsui Jun Imafuku Mikio Asakura Tohru Tsukamoto Miyuki Ino Noriko Saitoh Satoko Miyamura Kazuo Hasegawa

Abstract:	α₂-adrenergic receptors labeled by [³H]clonidine (α₂-antagonist) can be solubilized from the rat brain with a zwitterionic detergent, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate (CHAPS). CHAPS-solubilized receptors have the same characteristics of membrane-boundα₂-receptors in the brain, and the regulation of receptor binding by guanine nucleotides is retained in the soluble state.

Keywords:	α ₂-adrenergic receptor 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate solubilization guanine nucleotide rat brain
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