'Yin–Yang' functions of transforming growth factor-β and T regulatory cells in immune regulation |
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| Authors: | Yisong Y. Wan Richard A. Flavell |
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| Affiliation: | Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, New Haven, CT, USA. |
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| Abstract: | Summary: Transforming growth factor-β (TGF-β) and forkhead box p3-expressing T-regulatory (Treg) cells are critical in maintaining self-tolerance and immune homeostasis. The immune suppressive functions of TGF-β and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent studies revealed the positive roles of TGF-β and Treg cells in shaping the immune system and the inflammatory responses. This review discusses our and other's efforts in understanding the negative (Yin) as well as the positive (Yang) roles for TGF-β and Treg cells in immune regulation. |
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| Keywords: | TGF-β Treg Foxp3 Th2 IL-17 |
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