Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy |
| |
Authors: | Vaquero Javier Chung Chuhan Blei Andres T |
| |
Affiliation: | Section of Hepatology, Department of Medicine, Lakeside VAMC and Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA. |
| |
Abstract: | Hepatic encephalopathy and brain edema are important complications in the course of a patient with acute liver failure. Presumed unrelated for many years, increasing evidence suggests that an increase in brain water is seen in all forms of hepatic encephalopathy. Ammonia, traditionally linked to the pathogenesis of hepatic encephalopathy, plays an important role in the increase in brain water. In acute liver failure, an osmotic disturbance in the astrocyte, in combination with an alteration of cerebral blood flow results in overt brain edema and intracranial hypertension. In cirrhosis, magnetic resonance techniques indicate the presence of a brain osmotic disturbance. Several clinical factors modulate the development of brain swelling. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|