血小板与肝脏疾病研究进展

血小板主要参与机体凝血过程。近年研究发现,血小板及其储存释放的5-羟色胺还参与肝功能调节、肝损伤反应、肝再生等病理生理过程。这些新的发现有助于阐释肝脏缺血/再灌注损伤、肝再生和慢性肝病的发病机制;还可能根据其作用机制和作用靶点,为减轻肝损伤、减缓肝硬化进程、促进肝再生带来新的治疗希望,也可能为防治肝移植缺血/再灌注损伤提供新的方法。

Research Progresses of Platelet and Liver Diseases

Platelets are mainly involved in the process of blood coagulation.Recent studies have found that platelets and 5-hydroxytryptamine stored and released in platelets are also involved in the pathophysiology of regulating liver function,liver damage response and liver regeneration and so on.These new findings will be very helpful to explain the mechanism of liver ischemi-reperfusion injury,liver regeneration and chronic liver disease.it′s the mechanism and acting targets can also be made use to reduce liver damage and slow down the process of liver cirrhosis and promote liver regeneration,which may also bring along new methods to prevent and treat liver transplantation ischemia-reperfusion injury.