重症监护病房铜绿假单胞菌感染趋势及耐药监测

目的：了解重症监护病房铜绿假单胞菌（PA）的耐药率和抗菌药物使用变化情况,加强院内感染监测,指导临床合理用药。方法：分析我市三家综合性医院2006年1月～2010年12月重症监护病房各类送检标本中铜绿假单胞菌的感染趋势及耐药状况。结果：1 895例送检标本中共检出铜绿假单胞菌536株,检出率为28.3%,铜绿假单胞菌对15种常用抗菌药物呈不同程度的耐药,对阿米卡星、亚胺培南、环丙沙星等抗生素的耐药率较低。结论：铜绿假单胞菌是医院重症监护病房常见的病原菌,检出率、耐药率增长明显,必须加强抗菌药物合理应用的管理,严格消毒隔离措施,采用联合和交替用药等方法加以控制。

Analysis of the drug resistance and the infection trend of pseudomonas aeruginosa in intensive care unit

Objective: To investigate the changes of drug resistance rate of pseudomonas aeruginosa(PA) and the application of antibiotics in intensive care unit.Methods: The drug resistance and the infection trend of PA strains which were isolated from patients from January 2006 to December 2010 in three hospitals of our city were analyzed.Results: 536 strains of PA were isolated from 1 895 cases of sample,the total rate of isolation was 28.3%.There were different levels of drug resistance of PA to 15 kinds of common application antibiotics,and the drug resistance of PA to Amikacin,Imipenem,Ciprofloxacin was low.Conclusion: PA is the common pathogens in intensive care unit.The isolated rate and the drug resistance rate of PA are growth significantly.It is essential to strengthen the isolation measures,make reasonable use of antibiotics and adopt drug combination and replacement,in order to control PA infection.