缺血性卒中炎症机制的研究进展

炎症机制在动脉粥样硬化、斑块破裂、血栓形成和缺血性卒中的发生、发展过程中发挥重要作用。多重慢性感染或"感染负荷"可能是动脉粥样硬化和缺血性卒中的危险因素,急性感染可促进缺血性卒中的发生,炎症标志物(如高敏C反应蛋白)可预测缺血性卒中的发生及其预后。治疗上除传统的重组组织型纤溶酶原激活剂、他汀类药物外,目前研究的药物还包括内皮素拮抗剂、伊马替尼等,均发现其具有抗炎、抗氧化作用。

Research Progress of the Inflammatory Mechanisms of Ischemic Stroke

Inflammatory mechanisms play a central role in the pathogenesis and progression of atherosclerosis,plaque rupture,thrombosis,and ischemic stroke.Multiple chronic infectious exposures or "infectious burden" may contribute to atherosclerosisi and schemic stroke,acute infections have also been found to serve as stroke triggers.Inflammatory biomarkers such as high-sensitivity C-reactive protein have been identified as predictors of first stroke and prognosis after ischemic stroke.In addition to the traditional treatment of recombinant tissue plasminogen activator,statins,the current study of the drug include endothelin antagonists,drugs such as imatinib,are found to have the function of anti-inflammatory and anti-oxidation.