甘精胰岛素和阿卡波糖联合治疗2型糖尿病疗效观察

目的：研究甘精胰岛素和阿卡波糖合用治疗2型糖尿病（T2DM）的疗效及该治疗方案对胰腺β细胞分泌功能的改善。方法：90例T2DM患者均给予甘精胰岛素和阿卡波糖治疗16周,检测治疗前及治疗16周后的空腹血糖值（FPG）、餐后2 h血糖值（2 h PG）、糖化血红蛋白（HbA1c）、空腹C肽（FCP）、餐后C肽（PCP）的变化。结果：经16周治疗后患者FPG、2 h PG、HbA1c分别下降为（6.91±1.50）mmol/L（t=1.669）、（8.28±2.12）mmol/L（t=2.136）、（6.51±1.03）%（t=1.663）,较治疗前明显下降,差异有统计学意义（P〈0.05）;治疗后患者FCP、PCP分别上升为（3.42±0.42）μg/L（t=2.178）、（3.78±0.32）μg/L（t=2.752）,较治疗前明显上升,差异有统计学意义（P〈0.05）。结论：甘精胰岛素和阿卡波糖合用治疗T2DM降糖效果好,并具有改善胰腺β细胞的内分泌功能的作用。

Therapeutic efficacy of Glargine Insulin combined with Acarbose in the treatment of patients with type 2 diabetes mellitus

Objective: To study therapeutic efficacy of Glargine Insulin combined with Acarbose in the treatment of type 2 diabetes mellitus(T2DM) and the efficacy of secretory function of pancreatic β-cell protection and improvement.Methods: 90 patients with T2DM were given Glargine Insulin and Acarbose after 16 weeks of treatment.The change of fasting plasma glucose(FPG),postprandial 2 h blood glucose(2 h PG),glycosylated hemoglobin(HbA1c),fasting C peptide(FCP),postprandial C peptide(PCP) were detected after 16 weeks of treatment.Results: After 16 weeks of treatment in patients with FPG,2 h PG,HbA1c decreased as the(6.91±1.50) mmol/L(t=1.669),(8.28±2.12) mmol/L(t=2.136),(6.51±1.03)%(t=1.663) descent,obviously after therapy,the differences were significant(P<0.05).FCP,PCP were increased to(3.42±0.42) μg/L(t=2.178),(3.78±0.32) μg/L(t=2.752),both were higher than before treatment,there were significant differences(P<0.05).Conclusion: The treatment of Glargine Insulin combined with Acarbose in T2DM has a good hypoglycemic effect and can improve the endocrine function of pancreatic β-cell.