中药影响炎症免疫反应的机制研究进展

炎症免疫反应是血管系统的活体组织对损伤因子的防御反应,是由损伤因子引起的组织损伤。临床药理学对炎症免疫反应的研究集中于作用机制方面,而中药影响炎症免疫反应的机制包括影响下丘脑-垂体-肾上腺皮质轴的功能、炎性介质的作用、核因子的功能、活性氧的生成、细胞功能而导致凋亡以及神经内分泌激素的生成等。因许多化学药物在影响炎症免疫反应过程中存在严重不良反应,而中药的不良反应少,故中药影响炎症免疫反应的机制已受到广泛的关注。

Research Progress on the Mechanism of the Influences of Traditional Chinese Medicine on Inflammation Immunity

The inflammation immunity is a defense response of the living tissue of vascular system to the damaging factors,a tissue injury caused by the damaging factors.The clinical pharmacological research of the inflammation immunity focuses on the function mechanism,which includes influencing the function of hypothalamus-pituitary-adrenal axis,inflammatory medium,nuclear factor,the generation of reactive oxygen species,apoptosis resulted from the cell function and the generation of neuroendocrine hormone,etc.for traditional Chinese medicine(TCM).A lot of chemical medicines have serious adverse effects,while TCM has much less.Therefore,the mechanism of TCM influence on inflammation immunity has drawn extensive attention.