促红细胞生成素抑制心脏重构作用及其机制的研究进展

促红细胞生成素是一种造血细胞生长因子,主要用于治疗多种原因引起的贫血。近年来研究表明其具有多种非促造血方面的细胞保护作用,特别是在抑制心脏重构方面的作用日益受到广泛关注,但作用机制目前尚不十分明确,可能与抑制心肌细胞肥大和凋亡,抗炎、抗氧化,抑制成纤维细胞增殖,抑制胶原合成及影响基质金属蛋白酶活性等方面有关。其作用机制,特别是分子机制的阐明将为心血管疾病的治疗提供广阔的前景。

Progress of Erythropoietin Inhibiting Cardiac Remodeling and Its Mechanism

Erythropoietin is known as a classical hematopoietic cell growth factor,which has been used to treat anemia caused by different factors.However,recent evidence demonstrated several non-hematopoietic effects which could provide myocardial protection in patients.Especially,erythropoietin has been concerned increasingly because of the role of inhibiting cardiac remodeling,though the underlying mechanisms are not completely clear.They may be related to inhibition of myocardial hypertrophy,fibroblast proliferation and collagen synthesis anti-apoptosis,anti-inflammatory,antioxidant,and inhibiting the effects of matrix metalloproteinase activity and other factors.Its mechanism,especially the clarification of molecular mechanism will provide a broad prospect for the treatment of cardiovascular diseases.