精子来源与数量对单精子卵胞浆内注射术妊娠结局的影响

目的:分析不同精子来源和数量对单精子卵胞浆内注射术(ICSI)妊娠结局的影响。方法:2000年1月至2003年6月在本中心进行ICSI治疗而妊娠的271例,据精子来源与数量分为精液正常组(39例)、少弱精组(144例)与手术取精组(88例)。比较精液正常组、少弱精组、手术取精组的临床妊娠率、流产率、分娩率、妊娠并发症、分娩孕周、新生儿出生体重、畸形、围生儿死亡率等组间差异。结果:精液正常组、少弱精组与手术取精组患者的临床妊娠率、流产率、分娩率、双胎率、妊娠期高血压疾病发生率、前置胎盘发生率、早产率、分娩孕周、新生儿出生体重、先天性畸形发生率(4.5%、6.3%、4.0%)、围生儿死亡率差异均无显著性(P>0.05)。结论:精液正常组、少弱精组与手术取精组ICSI治疗后临床妊娠率、流产率、妊娠期并发症、新生儿出生体重、先天性畸形发生率、围生儿死亡率相似,不同精子来源与数量不影响ICSI治疗后的妊娠和围生儿结局。

Effect of Spermatozoa Origin and Quantity on Pregnancy Outcome after Intracyto Plasmic Sperm Injection

Objective: To analyze the effect of spermatoza origin and quantity on pregnancy outcome after intracytoplasmic sperm injection.Methods: A retrospective study was carried out to compare the rate of clinical pregnancy,pre-clinical and clinical abortion,delivery,pregnant complications,gestational age,and birth weight and malformation of neonatal,perinatal mortality in women receiving normal semen(n=39,group1),oligoasthenozoospermis(n=144,group2) and sperm obtained by surgery(n=88,group3) between January 2000 and June 2003.Results: The maternal age and infertile duration were comparable among three groups.There were no significant differences in rate of clinical pregnancy,abortion,birth,twin gestation,pregnancy-induced hypertension,placenta praevia,premature birth,gestational age when labor,congenital malformation,perinatal mortality(4.5% vs 6.3% vs 4.0%)and birth weight of neonatalamong three groups(P>0.05).Conclusions: The pregnancy and perinatal outcome after ICSI is neither affected by the origin of sperm nor by the quantity of sperm in the ejaculate.