一氧化氮与TIA发作的关系研究

探讨一氧化氮（ＮＯ）与ＴＩＡ发作的关系。测定２３例ＴＩＡ患者ＴＩＡ发作期和ＴＩＡ发作后第３ｄ血清中ＮＯ、超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量。研究发现，ＴＩＡ发作时ＮＯ、ＳＯＤ含量显著降低（Ｐ＜０．０５），ＭＤＡ含量显著增高（Ｐ＜０．００１）；ＴＩＡ发作后第３ｄ，ＮＯ含量回升至正常水平（Ｐ＞０．０５），ＳＯＤ含量增加但仍低于正常（Ｐ＜０．００５），而ＭＤＡ含量持续高于正常（Ｐ＜０．００１）。结果表明，ＮＯ含量降低与ＴＩＡ发作有关，ＴＩＡ发作后缺血再灌注期ＮＯ可能参与组织损伤。本文提示，ＮＯ对ＴＩＡ有防治作用，ＳＯＤ能增强ＮＯ的治疗作用，ＴＩＡ发作后宜积极抗氧化治疗。

The relation between nitric oxied and TIA

In order to study the relation between nitric oxide(NO)and 23 patient with transient ischemic attack (TIA), the serum NO, superoxide dismutase(SOD) , MDA activity was studied respectively during TIA onset and after 3 days of onset. At the same time, 28 age and sex-matched health persons were tested similarly as the control group. The results showed that the activity of NO and SOD was lower dramatically (P<0. 05) and that of MDA was high (P<0. 001) compared with the health control group during TIA onset. After 3 days of onset ,the activity of NO was normal (P>0. 05) and SOD activity was still lower (P<0. 005) ,whereas that of MDA was high continuously (P<0. 001 ) compared with the control group. This study suggests that there are relation between decline of NO activity and TIA onset ,and NO involves reperfusion injury to brain atfer TIA onset. We conclude that NO can prevent TIA onset and SOD can enhance the effect of NO, and antioxide treatment is necessary after TIA onset.