| 急性脑梗塞病人的红细胞膜ATP酶活性变化和自由基损伤 |
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| 引用本文： | 姚景莉 朱国行. 急性脑梗塞病人的红细胞膜ATP酶活性变化和自由基损伤[J]. 中风与神经疾病杂志, 1996, 13(3): 143-144 |
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| 作者姓名： | 姚景莉 朱国行 |
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| 作者单位： | 上海医科大学华山医院神经内科 200040(姚景莉，朱国行，秦震)，上海医科大学华山医院放射医学研究所 200040(陈识杰) |
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| 摘 要： | 测定33例急性脑梗塞病人的红细胞膜Na~ K~-ATP酶和Ca~(2 )Mg~(2 )-ATP酶活性及血浆MDA含量,红细胞SOD活性,与29例正常老年人作比较,发现急性脑梗塞病人的红细胞膜Na~ K~ -ATP酶和Ca~(2 )Mg~(2 )-ATP酶活性均降低,而血浆MDA含量升高,红细胞SOD活性下降。说明急性脑梗塞病人存在红细胞功能受损和自由基损害。这些变化的研究,对于进一步探讨脑梗塞的病理生理及其防治可能具有重要意义。
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| 关 键 词： | 急性脑梗塞 自由基 红细胞膜ATP酶 |
The change of erythrocyte membrane ATPase and the injury of free radical in acute cerebral infarction |
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| Yao Jingli,Zhu Guoxing,Qin Zhen,et al.. The change of erythrocyte membrane ATPase and the injury of free radical in acute cerebral infarction[J]. Journal of Apoplexy and Nervous Diseases, 1996, 13(3): 143-144 |
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| Authors: | Yao Jingli Zhu Guoxing Qin Zhen et al. |
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| Affiliation: | Yao Jingli,Zhu Guoxing,Qin Zhen,et al.Institute of Neurology,Hua Shan Hospital,Shanghai Medical University,Shanghai 200040. |
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| Abstract: | The activity of erythrocyte membrane Na K -ATPase and Ca2 Mg2 -ATPase ,the activity of erythrocyte superox-ide dismutase (SOD), the levels of plasma malonaldehyde (MDA) were measure in 33 acute cerebral infarction patients, compaired with 29 healthy age-paired volunteers. The activity of erythrocyte membrane. Na K - ATPase and Ca2 Mg2 - ATPase were decreased in acute cerebral infarction patients as compared with that in normal subject (P<0. 01). Plasnia DMA levels were increased and erythrocyte SOD activity decreased in acute cerebral infarction patients as compared with that in normal subjects(P<0. 01). It is considered there are disturbance of function of erythrocyte membrane and free radials in acute cerebral infarction. |
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| Keywords: | Acute cerebral infarction Free radical Erythrocyte membrane ATPase |
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