普遍脑萎缩与血液流变学关系的探讨

采用Ｈｕｃｋｍａｎｎ氏方法对１４２例颅脑ＣＴ平片进行脑室、脑沟测量，并逐一测定有关血液流变学指标：ＲＢＣ变形性、全血粘度、ＲＢＣ压积、血小板聚集率、纤维蛋白原含量，结果表明：（１）有随年龄增长逐渐出现普遍性脑萎缩的趋向，但大都在进入老年期后才日益明显；（２）普遍脑萎缩病人存在某些显著的血液流变学异常，如ＲＢＣ变形能力下降、全血粘度升高等；（３）显著皮层萎缩组与显著脑白质萎缩组血液流变学指标变化不尽相同，前者ＲＢＣ压积、全血粘度、纤维蛋白原含量，ＲＢＣ变形性明显高于后者，而后者的血小板聚集率高于前者。

The study of relationship between generalized cerebral atrophy and hemorrheology

We measured the width of ventricles and sulci on CT in 142 persons with Huckmann's method and their related hemorrheological indexes: RBC deformability,whole blood viscosity, hematocrit, platelet aggregability, plasma fibrinogen. The results showed that there occur generalized cerebral atrophy gradually with increasing of age, but changed obviously during serium. Generalized cerebral atrophy patients have obvious abnormal hemorrheological factors, such as, decreasing of RBC deformability ,increasing of whole blood viscosity and so on. The disturbanced hemorrheological factors of marked gyral atrophy is not all same as that of marked brain white matter atrophy. The former indexes of hematocrit,whole blood viscosity, plasma fibrinogen are higher than that of the latter, while the latter index of platelet aggregability was higher than that of former.