乌鲁木齐地区维汉两民族中冠心病患者糖蛋白Ⅲa基因多态性研究

Glycoprotein Ⅲa gene polymorphisms and risk for coronary artery disease in Chinese Urumqi Uygur and Han population

Objective To determine whether a variant(PlA2) of the membrane glycoprotein IIIa(GP IIIa) gene is associated with CAD. Furthermore,the association of the polymorphism with the classical risk factors was analyzed.Methods Blood was drawn from 105 patients (pt) and 56 controls, some of those undergoing angiography. A 266 base pair fragment of the GP IIIa gene was amplified by the polymerase chain reaction(PCR) and digested with the MspI restriction enzyme. Genotypes were identified after electrophoresis of digestion products in 2.0% agarose gel. Results Of the 105 patients(pt), 65 had acute (n=19) or previous MI,20 had unstable angina (UAP), and 20 had stable angina(SAP).The PlA2 allele was carried by 0% of CAD pt versus 1.8% of Non CAD control subjects in Chinese Urumqi Uygur and Han population. The PlA2 allele was carried by 0% of CAD pt versus 7.7% of Non CAD control subjects in Uygur population.The PlA2 allele was found in 0% of CAD pt versus 0% of Non CAD control subjects in Han population.Conclusions The PlA2 variant of the gene GP IIIa is not associated with CAD in Uygur population and Han population in Urumqi city of Xinjiang Uygur Autonomous Region.