| 荧光法测定氟康唑滴眼液的含量 |
| |
| 引用本文： | 白建伟,晋援朝,白林,晋薇. 荧光法测定氟康唑滴眼液的含量[J]. 医学争鸣, 2004, 25(9): 841-842 |
| |
| 作者姓名： | 白建伟 晋援朝 白林 晋薇 |
| |
| 作者单位： | 第四军医大学西京医院眼科,陕西,西安,710033;解放军总医院,普通外科,北京,100853;解放军总医院,药材处,北京,100853;第一军医大学学员旅18队,广东,广州,510515 |
| |
| 摘 要： | 目的:建立荧光法测定氟康唑滴眼液的含量. 方法:261 nm为激发波长,284 nm为发射波长,狭缝5 nm;光电倍增管增益:正常;时间扫描速度10 nm/min. 结果:氟康唑在0.002~0.026 g/L范围内线性关系良好. 回归方程Y=1.53 2.66X, r=0.9998. 3种浓度的平均回收率(n=9)分别为99.4%,100.6%,100.8%;相对标准偏差(RSD)分别为0.38%,0.63%和0.56%. 结论:本法专属性强,结果准确. 可用于氟康唑滴眼液的含量测定.
|
| 关 键 词： | 荧光法 氟康唑滴眼液 含量测定 |
| 文章编号： | 1000-2790(2004)09-0841-02 |
| 修稿时间： | 2004-03-07 |
Determination of Fluconazol Eye Drops by fluorospectrophotometry |
| |
| Abstract: | AIM: To determine Fluconazol Eye Drops by fluorospectrophotometry. METHODS: The excitation wavelength was 261 nm, emission wavelength 284 nm and bandpass 5 nm. The PM gain was normal and time scanning speed was 10 nm/min. RESULTS: The Fluconazol was linear in the range of 0.002-0.026 g/L for Fluconazol ( r = 0.9998). The recovery rate for the three concentration were 99.4%, 100.6% and 100.8% respectively, and the relative standard deviations (RSD) of the method were 0.38%, 0.63% and 0.56% , respectively. CONCLUSION: This method is easy, accurate and reproducible and can be used for the quality control of Fluconazol Eye Drops. |
| |
| Keywords: | fluorospectrophotometry fluconazol eye drops assay |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
