血液灌流联合血液透析治疗尿毒症26例观察

目的探讨使用血液灌流治疗尿毒症患者的疗效与安全性。方法维持性血液透析患者26例,采用血液灌流与血液透析(HP/HD)联合治疗方法与单纯血液透析(HD)方法对比(自身对照)。治疗前后检测中分子物质(MMS)、血尿素、肌酐、白蛋白及临床症状。结果血液灌流治疗能显著清除尿毒症患者体内的中分子物质,单次使用治疗2小时后MMS显著下降,单纯血液透析对MMS无影响,两者差异有明显统计学意义(P<0.01)。同时患者睡眠、食欲、皮肤瘙痒有不同程度改善。未发生其它任何副作用。结论作为清除MMS的治疗措施,血液灌流临床使用安全、疗效可靠、无副作用。

The clinical study of combined hemodialysls-hemoperfusion in chronic uremia

Objective To investigate the effect and safety of combined hemodialysis-resin hemoperfusion in uremia.Methods 26 uremia patients were treated with combined hemodialysis-resin hemoperfusion.Middle molecular subatances(MMS),urea and creatinine were detected before and after the treatment.Meanwhile,we compared the effect of combined hemodialysis-resin hemoperfusion procedure with conventional hemodialysis in uremic toxin clearance.Results MMS was reduced significantly in combined hemodialysis-hemoperfusion procedure(P<0.001).Compared with conventional hemodialysis,a combination of hemoperfusion and hemodialysis had a better effect in MMS clearance(P<0.001).Meanwhile,some clinical conditions(appetite,pruritus,insomnia) improved.We did not found any adverse effect.Conclusion Resin hemoperfusion can effectively clean MMS and was confirmed to be a safe and risk-free procedure.