三康胶囊对环磷酰胺所致免疫功能低下小鼠的保护作用

目的:观察三康胶囊对环磷酰胺所致免疫低下小鼠免疫功能的影响。方法:用环磷酰胺(100 mg/kg,ip)制备小鼠免疫低下模型,灌胃给予不同剂量的三康胶囊(250 mg/kg,500 mg/kg)和阳性对照药贞芪扶正胶囊(500mg/kg),观察小鼠外周血白细胞计数、免疫器官重量、单核吞噬细胞吞噬指数、血清溶血素水平和脾脏淋巴细胞转化指数。结果:对免疫功能低下小鼠,三康胶囊能增加外周血白细胞数量及免疫器官指数,增强单核吞噬细胞的吞噬能力,提高血清溶血素水平和脾脏淋巴细胞转化指数。结论:三康胶囊能够增强环磷酰胺所致免疫功能低下小鼠非特异性免疫和特异性免疫功能,对免疫失衡机体具有保护作用。

Protective Effect of Sankang Capsule on Immunity-deficiency Mice Induced by Cyclophosphamide

Objective: To study the immunomodulatory effect of Sankang Capsule(SKC) on the immunity-deficiency mice.Methods: The immunity-deficiency model was induced by intraperitoneal injection(ip) of cyclophosphamide(CTX) at the dose of 100 mg/kg in mice which were randomly divided into normal control group,immunity-deficiency model group,SKC treated group(250 mg/kg,500 mg/kg) and positive control group(500 mg/kg).The number of WBC in peripheral blood,the weight of immune organs,the phagocytosis activity of macrophage,the content of serum hemolysin and the proliferation of T lymphocyte in the spleen were measured.Results: The number of WBC,the weight of immune organs,the phagocytosis activity of macrophage,the content of serum hemolysin and the proliferation of T lymphocyte in the model group were all decreased compared with those of normal control group.After the administration of SKC,the index mentioned above was increased compared with those of model group.Conclusion: SKC has a protective effect on the immunity-deficiency mice,which may be related to the increasing of cellular immunity,humoral immunity and nonspecific immunity.