胆系恶性肿瘤NM23蛋白的表达及意义

本文应用ＡＢＣ免疫组化法研究胆囊癌和胆管癌组织中ＮＭ２３蛋白的表达及其意义。４０例胆囊癌ＮＭ２３蛋白阳性病例率为４２例胆管癌ＮＭ２３蛋白阳性病例率分别为６５％和５５％、高分化胆囊癌和胆管癌ＮＭ２３蛋白阳性病例率明显地高于低分化胆囊癌和胆管癌或未分化胆管癌；伴转移的胆囊癌和胆管癌ＭＮ２３蛋白阳性病例率明显低于未转移的胆囊癌和胆管癌。

The Expression and Significance of Nm23 Oncoprotein in the Malignant Neoplasms of Gallbladder and Bile Duct

The expressions and significance of NM23 oncoprotein were studied by immunohistochemical method in the 40 cases of gallbladder carcinoma and 42 cases of cholangiocarcinoma ,and 41 cases of pancreatic carcinoma. The results showed , ( 1 ) The positive cases rate of NM23 oncoprotein in malignant neoplasms of gallbladder ,bile duct was 65% , 55% . respectively. (2)The positive case rates of NM23 oncoprotein in well- differentatiated adenocarcinomas (gallbl-adder 18/23 ,bile duct 13/1 7 )were obviously higher than that in poor- ly-differentated adenocarcinoma (gallbladder 5/12 ,bile duct 7/16 ) . (3 )The positive case rates of NM23 onco- protein were significantly lower in the cases with metastasis (gallbladder 8/18 , bile duct 5/17)than in the cas- es without metastasis (gallbladder 18/22 , bile duct 18/25 ). These results suggested , ( 1 ) the expressions of NM23 oncoprotein might be related to the histological features ,metastatic or potentially metastatic character- ization of the malignant neoplasm of gallbladder and bile duct ,and pancreas. ( 2)NM23 oncoprotein might be an important marker in reflecting the biological behaviors and prognosis of maligant neoplasms of gallbladder and bile duct.