2010年度卫生部全国细菌耐药监测报告:非ICU住院感染患者细菌耐药监测

目的 了解全国2010年非ICU住院患者临床分离细菌分布及耐药性.方法 收集2010年1月1日-12月31日全国129所医院非ICU住院患者临床分离细菌药物敏感性试验数据,根据2010年美国临床实验室标准化研究所标准,用WHONET 5.6软件进行数据分析.结果 共获得临床分离菌216 872株,其中革兰阴性菌152 351株,占70.2％；革兰阳性菌64 521株,占29.8％；最常见的细菌依次为大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌、鲍氏不动杆菌和金黄色葡萄球菌；耐甲氧西林金黄色葡萄球菌与凝固酶阴性葡萄球菌的检出率分别为52.1％、83.8％；未发现耐万古霉素葡萄球菌,粪肠球菌和屎肠球菌对万古霉素耐药率分别为0.6％和3.3％,未发现耐利奈唑胺肠球菌属；耐青霉素肺炎链球菌检出率为10.7％；有5.9％和1.8％大肠埃希菌及9.1％和3.5％肺炎克雷伯菌对亚胺培南和美罗培南耐药；铜绿假单胞菌对碳青霉烯类抗菌药物的耐药率约为20.0％,鲍氏不动杆菌耐药率超过铜绿假单胞菌.结论 我国非ICU住院患者感染致病细菌耐药现象仍较为普遍,但同上年度相比,多数细菌耐药率未呈上升趋势.

Mohnarin report 2010:surveillance of antimicrobial resistance of clinical isolates from Non-ICU inpatients

OBJECTIVE To investigate the bacterial distribution and antimicrobial resistance of clinical isolates from non-ICU inpatients in China.METHODS The data of drug susceptibility testing of clinical isolates from non-ICU inpatients in 129 hospitals form Jan 1 to Dec 31,2010 were collected.The susceptibilities of isolates to antimicrobial agents were determined by CLSI 2010 guideline and the data were analyzed by WHONET 5.6 software.RESULTS A total of 216 872 clinical isolates were obtained,which included 152 315(70.2%) gram-negative bacterial isolates and 64 521(29.8%) gram-positive bacteria isolates.Escheichia coli,Pseudomonas aeroginosa,Klebsiella pneumoniae,Acinetobacter baumannii and Staphylococcus aureus were the most common isolates.The detection rates of methicillin-resistant S.aureus(MRSA) and coagulase-negative Staphylococcus(MRSCNS) were 52.1% and 83.8%,respectively;No vancomycin-resistant Staphylococcus strains were found,the resistance rates of E.faecalis and Enterococcus faecium to vancomycin were 0.6% and 3.3%,respectively.No linezolid-resistant Enterococcus isolates were found;the detection rate of penicillin-resistant Streptococcus pneumoniae(PRSP) was 10.7%;there were 5.9% and 1.8% of E.coli as well as 9.1% and 3.5% of K.pneumoniae isolates resistant to imipenem and meropenem.The resistance rate of P.aeruginosa to carbapenems was 20.0%,while the drug resistance rate of A.baumannii was higher than that of P.aeruginosa.CONCLUSION Drug resistance of pathogenic bacteria from non-ICU inpatients is universal in China,but compared with that of last year,the drug resistance rate of most isolates does not present an upward trend.