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五水头孢唑啉钠与奥硝唑氯化钠注射液配伍稳定性考察
引用本文:Liang Xuezheng,李茵,Su Lili.五水头孢唑啉钠与奥硝唑氯化钠注射液配伍稳定性考察[J].中国药业,2008,17(14):27-28.
作者姓名:Liang Xuezheng  李茵  Su Lili
作者单位:广西壮族自治区柳州市中医院,广西柳州,545001
摘    要:目的考察五水头孢唑啉钠与奥硝唑配伍的稳定性。方法在室温下(25℃)观察8h内注射用五水头孢唑啉钠(51mg/L)与奥硝唑氯化钠注射液(20mg/L)配伍液的pH值、外观及紫外光谱的变化,用紫外双波长分光光度法及系数倍率法分别测定五水头孢唑啉钠与奥硝唑的含量。结果五水头孢唑啉钠与奥硝唑配伍液的pH值、外观、含量无明显变化。结论注射用五水头孢唑啉钠与奥硝唑氯化钠注射液的配伍液在25℃下、8h内可配伍使用。

关 键 词:五水头孢唑啉钠  奥哨唑氯化钠注射液  配伍  稳定性

Compatible Stability of Cefazolin Sodium Pentahydrate Injection and Omidazole Sodium Chloride Injection
Liang Xuezheng,Li Yin,Su Lili.Compatible Stability of Cefazolin Sodium Pentahydrate Injection and Omidazole Sodium Chloride Injection[J].China Pharmaceuticals,2008,17(14):27-28.
Authors:Liang Xuezheng  Li Yin  Su Lili
Institution:Liang Xuezheng, Li Yin, Su Lili( 1. Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou, Guangxi, China 545001 ; 2. Guilin Medical College, Guilin, Guangxi, China 541004)
Abstract:Objective To study the compatible stability of cefazolin sodium pentahydrate with Omidazole Sodium Chioride Injection. Methods At the room temperature(25℃ ), the changes in pH value, appearance and UV spectrophotometry of the mixed liquid of cefazolin sodium pentahydrate with Omidezole Sodium Chloride Injection were observed within 8 h, at the same time, the content of both constituents were determined by dual ultraviolet wavelength spctrophotometry and K- ratio spectrophotometry. Results The mixed liquid of cefazolin sodium pentahydrate and Omidazole Sodium Chloride Injection had no evident variation in, pH value, appearance and content at 25℃ within 8 h. Conclusion Cefazolin sodium pentahydrate can be compatibly mixed with omidazole sodium chioride at 25℃ within 8 h.
Keywords:cefazolin sodium pentahydrate  Omidazole Sodium Chioride Injection  combination  compatible stability
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