婴幼儿血管瘤的临床特征及危险因素分析

目的总结婴幼儿血管瘤的临床特征,探讨发生婴幼儿血管瘤的危险因素。方法采用以医院为基础的病例对照研究方法。病例由337例婴幼儿血管瘤患者组成,对照由同期入住相同医院的337例未患此病的婴幼儿组成,采取1:1匹配。采用自行设计的调查表对患者母亲进行调查。阐述婴幼儿血管瘤患者的临床特征,应用Logistic回归分析评估婴幼儿血管瘤的潜在危险因素,并计算研究因素与血管瘤联系的比值比(OR)及其相应的95%可信区间(CI)。结果本研究研究对象的临床特征与先前研究报道的临床特征基本相同。血管瘤的显著性危险因素包括婴儿出生时体重过低(OR=1.895,95% CI:1.028～3.495,P=0.041),母亲从事体力劳动(OR=1.790,95% CI:1.016～3.153,P=0.044),母亲多胎妊娠(OR=1.6369,5%CI:1.053～2.541,P=0.029),母亲孕期使用药物(OR=2.0869,5% CI:1.497～2.907,P<0.001),及血管瘤的阳性家族史(OR=5.048,95% CI:2.412～10.563,P<0.001)。结论详细了解发生婴幼儿血管瘤的危险因素和临床特征,为有效预防和治疗这种疾病提供理论依据。

Clinical characteristics and risk factors for infantile hemangioma

【Objective】To summarize the clinical features of infantile hemangioma;to examine the risk factors for developing this disease.【Methods】 A hospital-based case control study was conducted.Cases(n =337) were patients with infantile hemangioma,and controls(n =260) were patients who had been admitted to the same hospital for diseases not related with infantile hemangioma.Cases and controls were matched with 1:1.All subjects were interviewed using a structured interviewer-administrated questionnaire.Clinical presentations were summarized.The odds ratios(OR) and 95% confidence intervals(CI) of infantile hemangioma for potential risk factors were analyzed by logistic regression.【Results】 The clinical features of our study patients were similar with that of previous studies.Significant risk factors for hemangiomas included low birth weight(OR =1.895,95% CI: 1.028~3.495,P =0.041),mother engaged in manual labor(OR =1.790,95% CI: 1.016~3.153,P =0.044),multiple gestation(OR =1.636,95% CI: 1.053~2.541,P =0.029),maternal medication use during the periconceptional period(OR =2.086,95% CI: 1.497~2.907,P <0.001),and a positive family history of hemangiomas(OR =5.048,95% CI: 2.412~10.563,P <0.001).【Conclusion】 To get the information in more detail the risk factors for infantile hemangioma and clinical characteristics,so effective protective and treat measures to infantile hemangioma can be used.