No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease |
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| Authors: | Mari TurunenSaila Vepsäläinen Petra MäkinenSeppo Helisalmi Annakaisa HaapasaloHilkka Soininen Mikko Hiltunen |
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| Institution: | Department of Neurology and Brain Research Unit, Clinical Research Centre/Mediteknia, University Hospital and University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland |
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| Abstract: | High temperature requirement 1 (HTRA1) gene is a plausible risk factor in Alzheimer's disease (AD) as it encodes a protease known to degrade amyloid-β peptide. Here we have studied whether single nucleotide polymorphisms (SNPs) in the HTRA1 gene or its nearby regions associated with AD in a large clinic-based case-control cohort originating from Finland. We did not observe significant association of the HTRA1 SNPs with AD among the whole case-control cohort or age-at-onset risk effect among AD patients. |
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| Keywords: | Alzheimer's disease HTRA1 Risk gene SNP |
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