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Lack of association between TLR4 Asp299Gly polymorphism and atherosclerosis: evidence from meta-analysis
Authors:Kui Zhang  Lushun Zhang  Bin Zhou  Yanyun Wang  Yaping Song  Li Rao  Lin Zhang
Institution:
  • a Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • b Department of Forensic Medicine, Zun Yi Medical College, Zun Yi, 563003, P.R. China
  • c Department of Pathology, Chengdu Medical College, Chengdu 610083, P.R. China
  • d Laboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R. China
  • e Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, PR China
    		•
    Abstract:

    Introduction

    Toll like receptor 4 (TLR4) expression was found to increase markedly in human atherosclerotic lesions, notably on macrophages and endothelial cells. TLR4 Asp299Gly polymorphism was associated with a blunted receptor activity and a subsequently diminished inflammatory response, and may subsequently reduce atherosclerosis (AS) risk. However, the results of molecular epidemiological studies remained inconsistent.

    Materials and methods

    The PubMed, CNKI databases were searched for all articles available. The OR corresponding to the 95% confidence interval (95% CI) was used to assess the association between TLR4 Asp299Gly polymorphism and risk of AS.

    Results

    15 case-control studies with 9,989 cases and 6,746 controls were available for this analysis. For control subjects, G allele frequency of TLR4 Asp299Gly polymorphism was ranging from 0.045 to 0.085. The G allele and the AG/GG genotypes were not associated with significantly risk of AS (OR = 1.02, 95% CI = 0.83 - 1.26 for G versus A and OR = 0.96, 95% CI = 0.80 - 1.15 for AG/GG versus AA, respectively) by random effects model.

    Conclusion

    These findings indicated that TLR4 Asp299Gly polymorphism may not play a role in AS development.
    Keywords:Atherosclerosis  Toll like receptor 4  Single nucleotide polymorphism  Meta-analysis
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