Association of tissue plasminogen activator and plasminogen activator inhibitor polymorphism with myocardial infarction: A meta-analysis |
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Authors: | Li-Li Gong Jian-Hao Peng Fei-Fei Han Jin Zhu Lian-Hua Fang Yue-Hua Wang Guan-Hua Du He-Yao Wang Li-Hong Liu |
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Institution: | a Beijing Chao-Yang Hospital affiliated with Beijing Capital Medical University, Beijing, Chinab Molecular Cardiology, Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, USAc Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100050, China |
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Abstract: | IntroductionTo investigate whether t-PA Alu repeat insertion/deletion (I/D) and PAI-1 4 G/5 G genetic variations are associated with the risk of MI.MethodsWe conducted a meta-analysis to assess the association between the t-PA I/D and PAI-1 4 G/5 G polymorphisms and risk of MI. We also performed subgroup analyses based on ethnicity (Caucasian, Asian, and African), gender and age. Forty one eligible studies including 12,461 cases and 14,993 controls were identified to evaluate the impact of PAI-1 4 G/5 G polymorphism on MI. Seven studies investigated the relationship between t-PA I/D and MI.ResultsThis meta-analysis revealed that the PAI-1 4 G allele (4 G/4 G and 4 G/5 G genotype) was associated with an increased risk of MI compared with the 5 G allele in the overall population (OR = 1.094, 95% CI = 1.021 - 1.172, p = 0.011). The relative risks of MI for 4 G/4 G genotype was increased when compared to 5 G/5 G genotype and 5 G allele, with odds ratio at 1.157 (95% CI 1.015 - 1.320, p = 0.029) and 1.126 (95% CI = 1.015 - 1.249, p = 0.025). However, the results show that the 4 G/5 G polymorphism risk for MI was not associated with ethnicity stratification as Caucasian, Asian or African population. No substantial differences in the genotype distributions were observed in the MI group and control group along the lines of gender and age. After multivariable analysis t-PA I/D polymorphism showed no consistent association with MI.ConclusionsThis study suggests that the 4 G/5 G polymorphism of PAI-1 may be a risk factor for MI in overall populations. |
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Keywords: | Myocardial infarction Ttissue plasminogen activator Plasminogen activator inhibitor-1 Polymorphism Meta-analysis |
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