| 兔急性肝缺血再灌注损伤CT灌注参数与肝损伤程度的相关性 |
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| 引用本文： | 郭成伟,张奕,李新云,曹希明,郑君惠,梁长虹. 兔急性肝缺血再灌注损伤CT灌注参数与肝损伤程度的相关性[J]. 中国医学影像技术, 2011, 27(4): 661-665 |
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| 作者姓名： | 郭成伟 张奕 李新云 曹希明 郑君惠 梁长虹 |
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| 作者单位： | 广东省医学科学院广东省人民医院南方医科大学附属华南医院放射科,广东,广州,510080 |
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| 基金项目： | 国家自然科学基金(30800269、30970798)、广东省科技计划基金(2005B10401040)、广东省自然科学基金(5001199)。 |
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| 摘 要： | 目的 观察兔肝急性缺血再灌注损伤(I/R)CT灌注参数的演变规律及与肝脏酶学指标(AST、ALT)的相关性。方法 新西兰大白兔24只,随机分成4组(0.5 h、2.0 h、6.0 h缺血再灌注组与对照组,每组6只),I/R组结扎肝左叶血供60 min后恢复,制备I/R模型。各组分别接受全肝CT灌注成像,在灌注图上测量肝动脉灌注量(HAP)、门静脉灌注量(HPP)、总灌注量(TLP)及肝动脉灌注指数(HPI)。检查结束后,经下腔静脉取血样,测定AST、ALT。结果 与对照组比较,HAP在0.5 h组显著降低(P<0.05),而在2.0 h组急剧升高(P<0.01);HPP在各I/R组均低于对照组(P均<0.01);TLP在0.5 h、6.0 h 组与对照组比较差异有统计学意义(P均<0.01); I/R各组HPI与对照组比较显著升高(P均<0.01);各I/R组血清AST、ALT显著高于对照组(P均＜0.05)。AST与HPI之间存在显著相关性(r=0.565, P<0.05);ALT与HAP、HPI、HPP均有相关性(r=0.418,P<0.05;r=0.767,P＜0.01;r=－0.674,P＜0.01)。结论 通过CT灌注参数,能够动态监测兔肝I/R后血流动力学改变。
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| 关 键 词： | 再灌注损伤 缺血 肝 兔 |
| 收稿时间： | 2010-09-16 |
| 修稿时间： | 2010-12-10 |
Correlation between CT perfusion parameters and degrees of hepatic injury in acute hepatic ischemia reperfusion injury rabbit models |
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| GUO Cheng-wei,ZHANG Yi,LI Xin-yun,CAO Xi-ming,ZHENG Jun-hui and LIANG Chang-hong. Correlation between CT perfusion parameters and degrees of hepatic injury in acute hepatic ischemia reperfusion injury rabbit models[J]. Chinese Journal of Medical Imaging Technology, 2011, 27(4): 661-665 |
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| Authors: | GUO Cheng-wei ZHANG Yi LI Xin-yun CAO Xi-ming ZHENG Jun-hui LIANG Chang-hong |
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| Affiliation: | Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General HospitalSouth China Hospital Affiliated to Southern Medical University, Guangzhou 510080, China;Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General HospitalSouth China Hospital Affiliated to Southern Medical University, Guangzhou 510080, China;Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General HospitalSouth China Hospital Affiliated to Southern Medical University, Guangzhou 510080, China;Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General HospitalSouth China Hospital Affiliated to Southern Medical University, Guangzhou 510080, China;Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General HospitalSouth China Hospital Affiliated to Southern Medical University, Guangzhou 510080, China;Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General HospitalSouth China Hospital Affiliated to Southern Medical University, Guangzhou 510080, China |
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| Abstract: | |
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| Keywords: | Reperfusion injury Ischemia Liver Rabbits |
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