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| 偏头痛相关血管活性药物实验筛选 | |
| 引用本文： | 章正祥,曹克刚,高永红,范吉平.偏头痛相关血管活性药物实验筛选[J].中国现代医生,2010,48(24):6-7,37. |
| 作者姓名： | 章正祥 曹克刚 高永红 范吉平 |
| 作者单位： | 1. 浙江中医药大学附属第一医院,浙江省中医院神经内科,浙江杭州,310006 2. 北京中医药大学东直门医院神经内科,北京,100700 3. 北京中医药大学东直门医院教育部重点实验室,北京,100700 4. 中国中医科学院,北京,100700 |
| 基金项目： | 国家自然科学基金资助项目;项目批准号 30600828 |
| 摘 要： | 目的偏头痛与血流异常相关,探讨偏头痛相关血管活性药物对血流速度的影响。方法采用脉冲多普勒血流计对肾上腺素组、去甲肾上腺素组、多巴胺(DA)组、溶媒组、正常组大鼠颈总动脉血流速度动态监测,评价血管活性药物对颈总动脉血流速度变化指数(BFVCI)的影响。结果肾上腺素、去甲肾上腺素、多巴胺均使血流速度下降。结论血流异常可能是偏头痛发病机制之一。 |
| 关 键 词： | 偏头痛 血管活性物质 血流速度 |
Migraine-related Vasoactive Drugs Experiment Screening |
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| Authors: | ZHANG Zhengxiang CAO Kegang GAO Yonghong FAN Jiping |
| Institution: | 1.Department of Neurology,First Affiliated Hospital,Zhejiang University of Traditional Chinese Medieine,Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou 310006,China;2.Department of Neurology,Beijing University of Chinese Medicine Affliated Dongzhimen Hospital,Beijingl00700,China;3.The Ministry of Education Key Laboratory,Beijing University of Chinese Medicine Affliated Dongzhimen Hospital,Beijing100700,China;4.China Academy of Chinese Medical Sciences,Beijing 100700,China) |
| Abstract: | Objective Blood flow abnormalities was associated with migraine,to explore the effect of migraine-related vasoactive drugs on blood flow velocity.Methods The rats were divided into epinephrine group,norepinephrine group,dopamine(DA) group,solvent group and normal group.Detected common carotid artery(CCA) blood flow velocity dynamically with pulsed doppler flow probe on the rat and evaluated the influence of vasoactive agent on blood flow velocity change index(BFVCI).Results Epinephrine,norepinephrine,DA can... |
| Keywords: | Migraine Vasoactive drugs Blood flow velocity |
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