Uterine rupture on unscarred uterus following labor induction for 2(nd) trimester termination of pregnancy with oral misoprostol: conservative management

Uterine rupture occurred at 25 weeks amenorrhea during pregnancy termination by misoprostol for fetal polykystosis. Rupture occurred on an unscared uterus after administration of significant accumulated doses of oral misoprostol (1400 g). The patient was managed conservatively and carried a subsequent pregnancy six months after the intervention. This accident occurs in 0.1% to 1% of the cases (0.59% in our experience) and only rare cases have been attributed to the use of misprostol. Clinicians should be particularly careful in patients with prior cesarean section or a weakened uterus.