| RANTES在银屑病患者角质形成细胞中的表达及其作用 |
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| 引用本文： | 唐玲,李泉,陈洁,于益芝,唐跃琼,郑茂荣. RANTES在银屑病患者角质形成细胞中的表达及其作用[J]. 中国麻风皮肤病杂志, 2003, 19(5): 426-427 |
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| 作者姓名： | 唐玲 李泉 陈洁 于益芝 唐跃琼 郑茂荣 |
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| 作者单位： | 1. 第二军医大学附属长海医院皮肤科,上海,200433
2. 第二军医大学免疫学研究所 |
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| 基金项目： | 国家自然科学基金 (30 2 71 2 0 2 )，国家 863计划(2 0 0 1AA2 1 50 91 ) |
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| 摘 要： | 目的：探讨银屑病皮损局部T淋巴细胞高度浸润的原因，并分析了趋化因子RANTES在此过程中的作用。方法：培养银屑病患者皮损处角质形成细胞，通过微孔小室实验检测其上清液对T淋巴细胞的趋化功能；通过酶联免疫吸附(ELISA)法检测上清液中RANTES的表达。结果：银屑病皮损处角质形成细胞培养上清液对T淋巴细胞的趋化能力明显强于正常对照组；其分泌的RANTES水平也高于正常人。结论：银屑病患者皮损局部T淋巴细胞的大量浸润，部分是由于角质形成细胞具有较强的趋化T淋巴细胞能力，而银屑病角质形成细胞中高表达的RANTES可能是发挥此作用趋化因子之一。
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| 关 键 词： | RANTES 银屑病 角质形成细胞 T淋巴细胞 发病机制 |
The role of RANTES expressed by keratinocytes from psoriatic lesions |
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| Tang Ling,Li Quan,Chen Jie,et al.. The role of RANTES expressed by keratinocytes from psoriatic lesions[J]. China Journal of Leprosy and Skin Diseases, 2003, 19(5): 426-427 |
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| Authors: | Tang Ling Li Quan Chen Jie et al. |
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| Affiliation: | Tang Ling,Li Quan,Chen Jie,et al. Department of Dermatology,Changhai Hospital,The Second Military Medical University,Shanghai,200433 |
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| Abstract: | Objective: To investigate the mechanisms of focal accumulation of T lymphocytes in psoriatic lesions and analyze the role of chemotaxis RANTES in the process.Methods: Chemotaxis of psoriatic lesional keratinocytes was detected by micropore loculus test. The concentration of RANTES in cultured supernatants of psoriatic lesional keratinocytes was determined by ELISA. Results: The chemotaxis of psoriatic lesional keratinocytes to T lymphocytes was stronger than that of controls. The concentration of RANTES in the cultured supernatants from psoriatic lesional keratinocytes also increased. Conclusion: Focal accumulation of T lymphocytes in psoriatic lesions may be partly related to stronger chemotaxis of psoriatic lesional keratinocytes to T lymphocytes. RANTES secreted by psoriatic keratinocytes may play one of key roles in the course. |
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| Keywords: | psoriasis chemotaxis keratinocyte RANTES |
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