| 电纺丝聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯纳米纤维的制备及表面亲水性(英文) |
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| 引用本文： | 李楠,王雪明,齐宏旭,翟俊山,王艳,胡平,朱建华.电纺丝聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯纳米纤维的制备及表面亲水性(英文)[J].中国组织工程研究与临床康复,2010,14(12). |
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| 作者姓名： | 李楠 王雪明 齐宏旭 翟俊山 王艳 胡平 朱建华 |
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| 作者单位： | 1. 解放军总参谋部总医院(解放军第309医院)消化科,北京市,100091
2. 清华大学化工系高分子材料研究室,北京市,100084 |
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| 基金项目： | 国家食品卫生质量监督检验中心"十一五重点攻关课题" |
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| 摘 要： | 背景:近年来聚乳酸、羟基磷灰石类复合材料支架具有良好的生物降解性和生物相容性而被广泛的研究,但是这类复合材料在增强材料界面的结合、调节材料的降解速率、改善材料的强度等方面仍不能满足理想的组织工程支架材料的要求.目的:探讨电纺丝法制备纳米纤维的结构形态及表面亲水性.方法:分别将聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯通过静电纺丝法制备纳米纤维膜,扫描电镜对纤维膜的结构形态进行分析,并观察在人体环境相近的磷酸盐缓冲溶液(37℃,pH 7.4)中浸泡不同时间的表面亲水性.结果与结论:通过静电纺丝技术可以将聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯3种材料制各成微纳米纤维结构,控制制备参数可以获得不同直径的纤维,样品随着在培养液中的浸泡时间延长,总体显示出接触角比初始降低,亲水性增强.
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| 关 键 词： | 聚乳酸 聚3羟基丁酸酯共聚4羟基丁酸酯 聚碳酸酯 电纺丝 亲水性 |
Electrospinning preparation and surface hydrophilicity investigation of poly(lactic acid),poly(3-hydroxybutyrate-o-4-hydroxybutyrate),and poly(propylene carbonate)nanometer fiber membranes |
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| Li Nan,Wang Xue-ming,Qi Hong-xu,Zhai Jun-shan,Wang Yan,Hu Ping,Zhu Jian-hua.Electrospinning preparation and surface hydrophilicity investigation of poly(lactic acid),poly(3-hydroxybutyrate-o-4-hydroxybutyrate),and poly(propylene carbonate)nanometer fiber membranes[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2010,14(12). |
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| Authors: | Li Nan Wang Xue-ming Qi Hong-xu Zhai Jun-shan Wang Yan Hu Ping Zhu Jian-hua |
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| Institution: | Li Nan1,Wang Xue-ming1,Qi Hong-xu2,Zhai Jun-shan1,Wang Yan2,Hu Ping2,Zhu Jian-hua1 1Department of Gastroenterology,PLA General Staff Headquarter General Hospital(309th Hospital of Chinese PLA),Beijing 100091,China,2Institute of Polymer Science , Technology,Department of Chemical Engineering,Tsinghua University,Beijing 100084 |
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| Abstract: | BACKGROUND:Recently,poly(lactic acid)/hydroxyapatite composite scaffolds have been widely used due to good biodegradation and biocompatibility.But poly(lactic acid)/hydroxyapatite composite material can not satisfy the requirements of ideal tissue-engineered scaffold materials owing to drawbacks in some aspects including enhancing material surface binding,adjusting material degradation velocity,and improving material intensity.OBJECTIVE:To investigate the structural morphology and surface hydrophilicity of ... |
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