认知行为疗法与西酞普兰对抑郁症患者局部脑血流的影响

目的探讨认知行为疗法与喜酞普兰对抑郁症患者局部脑血流的影响。方法38例抑郁症患者分为认知行为治疗组18例和西酞普兰药物治疗20例。采用99Tcm-双半胱乙酯局部脑血流灌注单光子发射计算机断层扫描（SPECT）显像结合感兴趣区（ROI）技术,对两组患者治疗前后的局部脑血流变化和汉密尔顿抑郁量表（HAMD）评分进行比较。结果治疗后,两组患者的抑郁症状均有改善,但西酞普兰组早于认知行为治疗组;两种治疗方法均可增加右基底节血流量,认知行为治疗组亦有右边缘系统扣带回后部局部血流量增加,西酞普兰组亦有右颞叶后部局部脑血流量增加。结论两种治疗方法对抑郁症均有效,但改善脑血流的部位不同。

Effects of Cognitive Behavioral Therapy and Citalopram on Regional Cerebral Blood Flow in Patients with Depression Disorder

Objective To explore the effects of cognitive behavioral therapy and citalopram on regional cerebral blood flow(rCBF)in the patients with depression disorder.Methods 38 patients with depression disorder were divided into the cognitive behavioral therapy group(n=18),and citalopram group(n=20).The rCBF changes and scores of Hanmilton Depression Scale(HAMD)of all patients in two groups were evaluated with 99Tcm-ECD single photon emission computed tomography(SPECT)and HAMD before and after treatment.Results After treatment,the symptoms of all patients in two groups improved,but the cases of the citalopram group got a rapid improvement compared with those of the cognitive behavioral therapy group.Both of two methods could increase blood flow in right basal ganglion;while,the blood flow also increased in right limbic system in the cognitive behavioral therapy group,and in right temporol lobule in the citalopram group.Conclusion Both cognitive behavioral therapy and citalopram are effect on symptoms of depression disorder,but affect blood flow in different parts.